In the apocalypse of 2163, a desperate Cole searches for Titan. Meanwhile, a captive Railly is faced with an impossible choice as the 12 Monkeys await the arrival of The Witness.
The show follows the journey of a time traveler, Cole, from the post-apocalyptic future. Using a dangerous and untested method of time travel, Cole arrives in the present day on a mission to locate and eradicate the source of a deadly plague that will eventually decimate 93.6% of the human race.
When all hope is lost, Cole must complete his cycle so that his younger self will one day arrive at the end with the answer.
The final battle against the Witness begins as the fate of time and mankind hangs in the balance; all the pieces finally come together to mark the end of the beginning.
The beginning of the end approaches as Cole and Cassie embark on their final mission.
Everything changes when the team finally climbs the steps and rings the bell in the Middle Ages.
Jones sends Hannah back in time to 2007 on a personal mission that could be the key to everything.
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