Katana master Tao (Steven Seagal) leads a special ops squad of ex-military vigilantes on a massacre mission, their target: vampires. On the post-apocalyptic globe, sucked dry by bloodthirsty vampires, a few remaining survivors are trapped in an infected hospital. Tao is their only hope and he knows the only cure is execution. Now it’s time for the last stand against the flesh-eating vampires and there’s nothing left to lose but the last of humanity.
When most of the population of Earth is infected by a virus and transformed into flesh eaters and blood drinking creatures, a group of hunters lead by Tao and his sword chase the vampire zombies to eliminate them. Six non-infected survivors try to find the exit of an abandoned hospital crowded of the infected creatures. Meanwhile, the military is ready to bomb the whole area.