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From Biosynthesis to Total Synthesis: Strategies and Tactics for Natural Products
By Alexandros L. Zografos (Ed)
Wiley | April 2016 | ISBN-10: 9781118751732 | 584 Pages | PDF | 23.9 mb
https://www.amazon.com/Biosynthesis-Total-Synthesis-Strategies-Products/dp/1118751736
Focusing on biosynthesis, this book provides readers with approaches and methodologies for modern organic synthesis. By discussing major biosynthetic pathways and their chemical reactions, transformations, and natural products applications; it links biosynthetic mechanisms and more efficient total synthesis.
• Describes four major biosynthetic pathways (acetate, mevalonate, shikimic acid, and mixed pathways and alkaloids) and their related mechanisms
• Covers reactions, tactics, and strategies for chemical transformations, linking biosynthetic processes and total synthesis
• Includes strategies for optimal synthetic plans and introduces a modern molecular approach to natural product synthesis and applications
• Acts as a key reference for industry and academic readers looking to advance knowledge in classical total synthesis, organic synthesis, and future directions in the field
CONTENTS
PREFACE xv
1 From Biosyntheses to Total Syntheses: An Introduction 1
SECTION I ACETATE BIOSYNTHETIC PATHWAY 19
2 Polyketides 21
3 Fatty Acids and their Derivatives 130
4 Polyethers 162
SECTION II MEVALONATE BIOSYNTHETIC PATHWAY 187
5 From Acetate to Mevalonate and Deoxyxylulose Phosphate Biosynthetic Pathways: an Introduction to Terpenoids 189
6 Monoterpenes and Iridoids 196
7 Sesquiterpenes 236
8 Diterpenes 279
9 Higher Terpenes and Steroids 296
SECTION III SHIKIMIC ACID BIOSYNTHETIC PATHWAY 331
10 Lignans, Lignins, and Resveratrols 333
SECTION IV MIXED BIOSYNTHETIC PATHWAYS: THE STORY OF ALKALOIDS 381
11 Ornithine and Lysine Alkaloids 383
12 Tyrosine Alkaloids 431
13 Histidine and Histidine-Like Alkaloids 473
14 Anthranilic Acid–Tryptophan Alkaloids 502
15 Future Directions of Modern Organic Synthesis 519
INDEX 548
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