Charlie and Manny treat a couple; Maggie evaluates the interns; Billy asks Maggie to be his mentor; Dawn tries to get her Chief of Surgery position back.
When charismatic Chief of Surgery Charlie Harris at Toronto's Hope-Zion Hospital ends up in a coma, he leaves the hospital in chaos - and his fiancée and fellow surgeon, Alex Reid, in a state of shock. Along with newly-arrived star surgeon, Joel Goran, Alex races to save Harris' life. As the action unfolds, comatose Dr. Harris explores the hospital halls in "spirit" form, not sure if he's a ghost or a figment of his own imagination. Reid, along with her fellow doctors, press on to save his life and those of their other patients, as they deal with the complicated and courageous decisions that are made in their daily struggle to keep hope alive.
Following a mass casualty accident involving a bus full of teenagers, Alex & Charlie rush to the scene to try and save the kids while waiting for backup to arrive. The Hope Zion Hospital family must band together to overcome the tragedy and move on to the next chapter of their lives.
Alex and Charlie put their wedding plans aside; Zach takes a special interest in a case; a coma patient who wakes up with no memory.
Alex has to put her concerns for Charlie aside when a chance to perform a cancer surgery arises.
The board questions the hospital staff about Charlie's behaviour; a patient convinces Alex to use new-age techniques; Shahir agrees to do an in-utero surgery.
Alex is challenged about the value of holistic medicine; Charlie's abilities are questioned; two filmmakers go to Hope Zion Hospital
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