Team Flash confront a new bus meta, Matthew AKA Melting Pot, who has the ability to swap people’s DNA. During a battle with Team Flash, Matthew accidentally takes Barry’s speed away and gives it to Iris. Now, with a new threat unleashed on Central City, Barry must act as the team leader while Iris takes on the mantle of superhero speedster in order to defeat their new foe.
After a particle accelerator causes a freak storm, CSI Investigator Barry Allen is struck by lightning and falls into a coma. Months later he awakens with the power of super speed, granting him the ability to move through Central City like an unseen guardian angel. Though initially excited by his newfound powers, Barry is shocked to discover he is not the only "meta-human" who was created in the wake of the accelerator explosion – and not everyone is using their new powers for good. Barry partners with S.T.A.R. Labs and dedicates his life to protect the innocent. For now, only a few close friends and associates know that Barry is literally the fastest man alive, but it won't be long before the world learns what Barry Allen has become... The Flash.
Barry and Iris greet their future children, XS and Bart, only for a shocking secret to threaten their new familial harmony. Meanwhile, the Godspeed war intensifies and threatens to destroy Central City.
John Diggle arrives in Central City with a weapon to help Barry stop the Godspeed War. Meanwhile, Allegra and Ultraviolet's new bond is put to the ultimate test, while Joe and Kristen Kramer are hunted by a former colleague of hers.
When an army of Godspeeds attack Central City, Barry and Iris must put their family plans on hold and focus on the latest threat to their home. Meanwhile, Chillblaine is released from prison and claims to be reformed but Frost has her doubts.
When Ultraviolet returns to Central City, Allegra is determined to find her cousin and change her heart. Meanwhile, Joe finds evidence that Kristen Kramer may not be the good cop she appears to be.
Cecile is forced to confront her past in order to break free from a psychic prison. Meanwhile, Chester takes over for Cisco but makes a mistake that puts Barry in serious danger. Joe investigates Kristen Kramer's old military ties and discovers an unsettling truth.
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